HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 56049

HXB2 Location  Nef(188-196)   Nef Epitope Map
View variants at this location
Epitope RLAFHHMAR   Epitope Alignment
Variants
RLAFHHvAR   observed variant
Epitope Name RR9(Nef)
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  1954
Epitope Seq.  RLAFHHMAR
Variant Seq.  RLAFHHvAR
Mutations M/V
Epitope Location M7V
HXB2 Location M194V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note This Asian B Clade optimal epitope differs from the consensus B at one position. It is predicted to be HLA-B52 restricted. Experimentally, B clade consensus peptide was used to challenge CTL response in subjects commonly carrying the Asian B-type epitope.

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health