HIV molecular immunology database
Found 1 matching record:
HXB2 Location | Nef(106-114) | Nef Epitope Map
View variants at this location |
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Epitope |
RQDILDLWV
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Epitope Alignment | ||||
Variants |
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Epitope Name | RV9(Nef) | |||||
Species (MHC/HLA) | human |
Showing all: 1 variant(s).
Variant ID. | 1946 |
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Epitope Seq. | RQDILDLWV |
Variant Seq. | RQDILDLWi |
Mutations | V/I |
Epitope Location | V9I |
HXB2 Location | V114I |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | This Asian B Clade optimal epitope differs from the consensus B at one position. It is predicted to be HLA-B13 restricted. Experimentally, B clade consensus peptide was used to challenge CTL response in subjects commonly carrying the Asian B-type epitope. |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.