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Displaying record number 55988

HXB2 Location Nef(106-114) Nef Epitope Map
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Epitope

RQDILDLWV

Epitope Alignment

Variants

RQDILDLWi observed variant

Epitope Name RV9(Nef)

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1946`
Epitope Seq.	`RQDILDLWV`
Variant Seq.	`RQDILDLWi`
Mutations	V/I
Epitope Location	V9I
HXB2 Location	V114I
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This Asian B Clade optimal epitope differs from the consensus B at one position. It is predicted to be HLA-B13 restricted. Experimentally, B clade consensus peptide was used to challenge CTL response in subjects commonly carrying the Asian B-type epitope.

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.