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Found 1 matching record:

Displaying record number 55976

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTYKGAL   Epitope Alignment
Variants
RPMTYKaAv   observed variant
RPMTYKaAL   observed variant
Epitope Name RL9(Nef)
Species (MHC/HLA human(B7)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1942
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKaAv
Mutations G/A L/V
Epitope Location G7A L9V
HXB2 Location G83A L85V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note This Asian B Clade optimal epitope differs from the consensus B at two positions. It is predicted to be HLA-B7 restricted. Experimentally, B clade consensus peptide was used to challenge CTL response in subjects commonly carrying the Asian B-type epitope.


Variant ID.  1943
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKaAL
Mutations G/A
Epitope Location G7A
HXB2 Location G83A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note This Asian B Clade optimal epitope differs from the consensus B at one position. It is predicted to be HLA-B7 restricted. Experimentally, B clade consensus peptide was used to challenge CTL response in subjects commonly carrying the Asian B-type epitope.

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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