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Found 1 matching record:

Displaying record number 55975

HXB2 Location  Nef(71-79)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPM   Epitope Alignment
Variants
tPQVPLRPM   observed variant
Epitope Name TM9(Nef)
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1941
Epitope Seq.  RPQVPLRPM
Variant Seq.  tPQVPLRPM
Mutations R/T
Epitope Location R1T
HXB2 Location R71T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note This Asian B Clade optimal epitope differs from the consensus B at one position. It is predicted to be HLA-B7 restricted. Experimentally, B clade consensus peptide was used to challenge CTL response in subjects commonly carrying the Asian B-type epitope.

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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