HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 55858

HXB2 Location  Nef(13-20)   Nef Epitope Map
View variants at this location
Epitope WPAIRERM   Epitope Alignment
WPAIRaRM   diminished response
Epitope Name WM8
Species (MHC/HLA human(B*08)

Variant Details

Showing all: 1 variant(s).

Variant ID.  1091
Epitope Seq.  WPAIRERM
Variant Seq.  WPAIRaRM
Mutations E/A
Epitope Location E6A
HXB2 Location E18A
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note The patient's autologous WM8 sequence differed from the consensus (WPTVRERM) at 2 positions. A partial escape emerged 6 years post-infection.


Maurer2008 Katja Maurer, Ellen G. Harrer, Andreas Goldwich, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Bernd Spriewald, Sandra M. Mueller, Thomas Harrer, and German Competence Network for HIV/AIDS. Role of Cytotoxic T-Lymphocyte-Mediated Immune Selection in a Dominant Human Leukocyte Antigen-B8-Restricted Cytotoxic T-Lymphocyte Epitope in Nef. J. Acquir. Immune Defic. Syndr., 48(2):133-141, 1 Jun 2008. PubMed ID: 18391752. Show all entries for this paper.

Questions or comments? Contact us at
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health