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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 55388

HXB2 Location  Vif(149-157)   Vif Epitope Map
View variants at this location
Epitope ALAALITPK   Epitope Alignment
Variants
ALtALITPK   observed variant
ALtALIkPK   observed variant
ltAALtkPK   observed variant
ALtALIatK   observed variant
ALAAvITPK   observed variant
ALAALvTPK   observed variant
ALAALIrPK   observed variant
Epitope Name VIf 149
Species (MHC/HLA human(A2)

Variant Details

Showing all: 7 variant(s).


Variant ID.  1679
Epitope Seq.  ALAALITPK
Variant Seq.  ALtALITPK
Mutations A/T
Epitope Location A3T
HXB2 Location A151T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subjects Pt18, Pt30 carried this variant and were unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1680
Epitope Seq.  ALAALITPK
Variant Seq.  ALtALIkPK
Mutations A/T T/K
Epitope Location A3T T7K
HXB2 Location A151T T155K
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt15 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1681
Epitope Seq.  ALAALITPK
Variant Seq.  ltAALtkPK
Mutations A/L L/T I/T T/K
Epitope Location A1L L2T I6T T7K
HXB2 Location A149L L150T I154T T155K
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt21 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1682
Epitope Seq.  ALAALITPK
Variant Seq.  ALtALIatK
Mutations A/T T/A P/T
Epitope Location A3T T7A P8T
HXB2 Location A151T T155A P156T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt23 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1684
Epitope Seq.  ALAALITPK
Variant Seq.  ALAAvITPK
Mutations L/V
Epitope Location L5V
HXB2 Location L153V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1685
Epitope Seq.  ALAALITPK
Variant Seq.  ALAALvTPK
Mutations I/V
Epitope Location I6V
HXB2 Location I154V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt17 carried this variant and was unable to recognize the challenge HXB2 form, ALAALITPK.


Variant ID.  1686
Epitope Seq.  ALAALITPK
Variant Seq.  ALAALIrPK
Mutations T/R
Epitope Location T7R
HXB2 Location T155R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt33 carried this variant and cross-recognized the challenge HXB2 form, ALAALITPK.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


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