HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 55372

HXB2 Location  Gag(433-440)   Gag Epitope Map
View variants at this location
Epitope FLGKIWPS   Epitope Alignment
Variants
FLGKIWsS   observed variant
FLGrIWPS   observed variant
Epitope Name Gag 433
Species (MHC/HLA human(A2)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1692
Epitope Seq.  FLGKIWPS
Variant Seq.  FLGKIWsS
Mutations P/S
Epitope Location P7S
HXB2 Location P439S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt16 carried this variant and was able to cross-recognize the challenge HXB2 epitope, FLGKIWPS. Of the 9 subjects that did carry the HXB2 epitope sequence, only 3, Pt30, Pt33 and Pt41 were able to recognize it.


Variant ID.  1693
Epitope Seq.  FLGKIWPS
Variant Seq.  FLGrIWPS
Mutations K/R
Epitope Location K4R
HXB2 Location K436R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Subject Pt43 carried this variant and was able to cross-recognize the challenge HXB2 epitope, FLGKIWPS.

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health