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Displaying record number 55103

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIImGLNK   diminished response; escape documented in this paper; TCR related mutation
KkWIILGLNK   diminished response
KtWIILGLNK   diminished response
KkWIImGLNK   diminished response; escape documented in this paper
KtWIImGLNK   diminished response; escape documented in this paper
Epitope Name KK10
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 5 variant(s).


Variant ID.  949
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type DR: diminished response
E: escape documented in this paper
TCR: TCR related mutation
Method CD8 T-cell Elispot - IFNy
Note Mutation does not affect binding to HLA, peptide processing, or viral fitness. Variant was very poorly recognized by KK10-specific CTLs, but it recruited an alternative TCRalpha and beta during chronic infection, being immunogenic enough to elicit a de novo CTL response. Also, enhanced binding of HLA-B*2705-KK10-L6M complex to Immunoglobulin-like transcript-4 (ILT4) occurred, resulting in an impairment of DC maturation and function as measured by the markers HLA-DR, CD83, CD40, CD180 and CD86.


Variant ID.  950
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Variant was recognized by CTLs, but the avidity of recognition decreased by ˜10-fold.


Variant ID.  951
Epitope Seq.  KRWIILGLNK
Variant Seq.  KtWIILGLNK
Mutations R/T
Epitope Location R2T
HXB2 Location R264T
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Variant was recognized by CTLs, but the avidity of recognition decreased by ˜10-fold.


Variant ID.  952
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type DR: diminished response
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant was very poorly recognized by CTLs.


Variant ID.  953
Epitope Seq.  KRWIILGLNK
Variant Seq.  KtWIImGLNK
Mutations R/T L/M
Epitope Location R2T L6M
HXB2 Location R264T L268M
Mutation Type DR: diminished response
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant was very poorly recognized by CTLs.

References

Lichterfeld2007a Mathias Lichterfeld, Daniel G. Kavanagh, Katie L. Williams, Beenu Moza, Stanley K. Mui, ToshiYuki Miura, Rohini Sivamurthy, Rachel Allgaier, Florencia Pereyra, Alicja Trocha, Margaret Feeney, Rajesh T. Gandhi, Eric S. Rosenberg, Marcus Altfeld, Todd M. Allen, Rachel Allen, Bruce D. Walker, Eric J. Sundberg, and Xu G. Yu. A Viral CTL Escape Mutation Leading to Immunoglobulin-Like Transcript 4-Mediated Functional Inhibition of Myelomonocytic Cells. J. Exp. Med., 204(12):2813-2824, 26 Nov 2007. PubMed ID: 18025130. Show all entries for this paper.


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