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Displaying record number 55101

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KkWIILGLNK   replicative capacity reduced
KRWIImGLNK   replicative capacity is not abrogated
KkWIImGLNK   replicative capacity reduced
{a...}KRWIILGLNK   replicative capacity is not abrogated
{a...}KkWIILGLNK   replicative capacity is not abrogated
{a...}KkWIImGLNK   replicative capacity is not abrogated
{t...}KkWIImGLNK   replicative capacity is not abrogated; replicative capacity reduced
Epitope Name KK10
Species (MHC/HLA human

Variant Details

Showing all: 7 variant(s).


Variant ID.  1593
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type RCR: replicative capacity reduced
Method Relative replication capacity assay
Note This R264K mutation abrogates replicative capacity of the virus. Decreased replication is seen under the influence of Cyclophilin A, while increased replication is seen when treated with Cyclosporin A.


Variant ID.  1594
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type RCOK: replicative capacity is not abrogated
Method Relative replication capacity assay
Note This L268M mutation does not affect replicative capacity of the virus.


Variant ID.  1595
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type RCR: replicative capacity reduced
Method Relative replication capacity assay
Note This R264K, L268M mutation abrogates replicative capacity of the virus. Increased replication is seen when treated with Cyclosporin A.


Variant ID.  2305
Epitope Seq.  {S...}KRWIILGLNK
Variant Seq.  {a...}KRWIILGLNK
Mutations S/A
Epitope Location S-90A
HXB2 Location S173A
Mutation Type RCOK: replicative capacity is not abrogated
Method Relative replication capacity assay
Note This upstream S173A mutation does not affect replicative capacity of the virus.


Variant ID.  2306
Epitope Seq.  {S...}KRWIILGLNK
Variant Seq.  {a...}KkWIILGLNK
Mutations R/K S/A
Epitope Location R2K S-90A
HXB2 Location R264K S173A
Mutation Type RCOK: replicative capacity is not abrogated
Method Relative replication capacity assay
Note This S173A, R264K mutation does not affect replicative capacity of the virus.


Variant ID.  2309
Epitope Seq.  {S...}KRWIILGLNK
Variant Seq.  {a...}KkWIImGLNK
Mutations R/K L/M S/A
Epitope Location R2K L6M S-90A
HXB2 Location R264K L268M S173A
Mutation Type RCOK: replicative capacity is not abrogated
Method Relative replication capacity assay
Note This triple S173A, R264K , L268M mutation does not affect replicative capacity of the virus, and brings its activity back to that of wild type. Increased replication is seen under the influence of Cyclophilin A, while decreased replication is seen when treated with Cyclosporin A.


Variant ID.  2310
Epitope Seq.  {S...}KRWIILGLNK
Variant Seq.  {t...}KkWIImGLNK
Mutations R/K L/M S/T
Epitope Location R2K L6M S-90T
HXB2 Location R264K L268M S173T
Mutation Type RCOK: replicative capacity is not abrogated
RCR: replicative capacity reduced
Method Relative replication capacity assay
Note This triple A237T, R264K , L268M mutation does not affect replicative capacity of the virus. Decreased replication is seen when treated with Cyclosporin A.

References

Schneidewind2007 Arne Schneidewind, Mark A. Brockman, Ruifeng Yang, Rahma I. Adam, Bin Li, Sylvie Le Gall, Charles R. Rinaldo, Sharon L. Craggs, Rachel L. Allgaier, Karen A. Power, Thomas Kuntzen, Chang-Shung Tung, Montiago X. LaBute, Sandra M. Mueller, Thomas Harrer, Andrew J. McMichael, Philip J. R. Goulder, Christopher Aiken, Christian Brander, Anthony D. Kelleher, and Todd M. Allen. Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication. J. Virol., 81(22):12382-12393, Nov 2007. PubMed ID: 17804494. Show all entries for this paper.


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