Search the Epitope Variant and Escape Mutation Database

Help

Found 1 matching record:

Displaying record number 551

HXB2 Location Pol(547-556) Pol Epitope Map
View variants at this location

PIQKETWETW

`PIQKETWEaW`		susceptible form
`PIQKEaWETW`		susceptible form
`PIQKETWdaW`		susceptible form

Species (MHC/HLA) human(A*32:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`1275`
Epitope Seq.	`PIQKETWETW`
Variant Seq.	`PIQKETWEaW`
Mutations	T/A
Epitope Location	T9A
HXB2 Location	T555A
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	Other
Note	Variant epitope PIQKETWEaW was able to elicit a lytic response from Subject 15160's CTL and it was found in 6/7 samples of subject's autologous viral sequences.

Variant ID.	`4356`
Epitope Seq.	`PIQKETWETW`
Variant Seq.	`PIQKEaWETW`
Mutations	T/A
Epitope Location	T6A
HXB2 Location	T552A
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	Other
Note	This variant, PIQKEaWETW, was detected in a mother-infant transmission study. The variant was recognized by index epitope-specific CTL clones.

Variant ID.	`4357`
Epitope Seq.	`PIQKETWETW`
Variant Seq.	`PIQKETWdaW`
Mutations	E/D T/A
Epitope Location	E8D T9A
HXB2 Location	E554D T555A
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	Other
Note	Variant epitope PIQKETWdaW was able to elicit a lytic response from Subject 15160's CTL though it was not found in the subject's autologous viral sequences.

References

Harrer1996b T. Harrer, E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. Cytotoxic T Lymphocytes in Asymptomatic Long-Term Nonprogressing HIV-1 Infection. Breadth and Specificity of the Response and Relation to In Vivo Viral Quasispecies in a Person with Prolonged Infection and Low Viral Load. J. Immunol., 156:2616-2623, 1996. PubMed ID: 8786327. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.