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Found 1 matching record:

Displaying record number 551

HXB2 Location  Pol(547-556)   Pol Epitope Map
View variants at this location
Epitope PIQKETWETW   Epitope Alignment
Variants
PIQKETWEaW   susceptible form
PIQKEaWETW   susceptible form
PIQKETWdaW   susceptible form
Species (MHC/HLA human(A*32:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1275
Epitope Seq.  PIQKETWETW
Variant Seq.  PIQKETWEaW
Mutations T/A
Epitope Location T9A
HXB2 Location T555A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Other
Note Variant epitope PIQKETWEaW was able to elicit a lytic response from Subject 15160's CTL and it was found in 6/7 samples of subject's autologous viral sequences.


Variant ID.  4356
Epitope Seq.  PIQKETWETW
Variant Seq.  PIQKEaWETW
Mutations T/A
Epitope Location T6A
HXB2 Location T552A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Other
Note This variant, PIQKEaWETW, was detected in a mother-infant transmission study. The variant was recognized by index epitope-specific CTL clones.


Variant ID.  4357
Epitope Seq.  PIQKETWETW
Variant Seq.  PIQKETWdaW
Mutations E/D T/A
Epitope Location E8D T9A
HXB2 Location E554D T555A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Other
Note Variant epitope PIQKETWdaW was able to elicit a lytic response from Subject 15160's CTL though it was not found in the subject's autologous viral sequences.

References

Harrer1996b T. Harrer, E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. Cytotoxic T Lymphocytes in Asymptomatic Long-Term Nonprogressing HIV-1 Infection. Breadth and Specificity of the Response and Relation to In Vivo Viral Quasispecies in a Person with Prolonged Infection and Low Viral Load. J. Immunol., 156:2616-2623, 1996. PubMed ID: 8786327. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


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