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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 55007

HXB2 Location  Gag(259-267)   Gag Epitope Map
View variants at this location
Epitope GEIYKRWII   Epitope Alignment
Variants
GdIYrRWII   non-susceptible form
rkIYKRWII   non-susceptible form
GdIYrkWIv   non-susceptible form
GnIYrRWIq   non-susceptible form
GEIYKRWIv   diminished response; susceptible form
GdIYKRWII   diminished response; susceptible form
GdIYKRWIv   diminished response; non-susceptible form; susceptible form
Epitope Name GEI
Species (MHC/HLA human(B*08:01)

Variant Details

Showing all: 7 variant(s).


Variant ID.  1805
Epitope Seq.  GEIYKRWII
Variant Seq.  GdIYrRWII
Mutations E/D K/R
Epitope Location E2D K5R
HXB2 Location E260D K263R
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note None of the patients tested responded to this variant.


Variant ID.  1806
Epitope Seq.  GEIYKRWII
Variant Seq.  rkIYKRWII
Mutations G/R E/K
Epitope Location G1R E2K
HXB2 Location G259R E260K
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note None of the patients tested responded to this variant.


Variant ID.  1807
Epitope Seq.  GEIYKRWII
Variant Seq.  GdIYrkWIv
Mutations E/D K/R R/K I/V
Epitope Location E2D K5R R6K I9V
HXB2 Location E260D K263R R264K I267V
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note None of the patients tested responded well to this variant.


Variant ID.  1808
Epitope Seq.  GEIYKRWII
Variant Seq.  GnIYrRWIq
Mutations E/N K/R I/Q
Epitope Location E2N K5R I9Q
HXB2 Location E260N K263R I267Q
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note None of the patients tested responded to this variant.


Variant ID.  1809
Epitope Seq.  GEIYKRWII
Variant Seq.  GEIYKRWIv
Mutations I/V
Epitope Location I9V
HXB2 Location I267V
Mutation Type DR: diminished response
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note Some patients had response at the level of the response to the index peptide. 2 patients had about 50% of the original response.


Variant ID.  1810
Epitope Seq.  GEIYKRWII
Variant Seq.  GdIYKRWII
Mutations E/D
Epitope Location E2D
HXB2 Location E260D
Mutation Type DR: diminished response
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note Some patients had response at the level of the response to the index peptide. 2 patients had about 50% of the original response.


Variant ID.  1811
Epitope Seq.  GEIYKRWII
Variant Seq.  GdIYKRWIv
Mutations E/D I/V
Epitope Location E2D I9V
HXB2 Location E260D I267V
Mutation Type DR: diminished response
NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note One patient responded at 80% of original response, 2 at 60%, 1 at 40% and 1 at 10%.

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


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