Found 1 matching record:
HXB2 Location | Gag(259-267) | Gag Epitope Map
View variants at this location |
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Epitope |
GEIYKRWII
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Epitope Alignment | ||||||||||||||||||||||
Variants |
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Epitope Name | GEI | |||||||||||||||||||||||
Species (MHC/HLA) | human(B*08:01) |
Showing all: 7 variant(s).
Variant ID. | 1805 |
---|---|
Epitope Seq. | GEIYKRWII |
Variant Seq. | GdIYrRWII |
Mutations | E/D K/R |
Epitope Location | E2D K5R |
HXB2 Location | E260D K263R |
Mutation Type | NSF: non-susceptible form |
Method | CD8 T-cell Elispot - IFNy, Tetramer binding |
Note | None of the patients tested responded to this variant. |
Variant ID. | 1806 |
---|---|
Epitope Seq. | GEIYKRWII |
Variant Seq. | rkIYKRWII |
Mutations | G/R E/K |
Epitope Location | G1R E2K |
HXB2 Location | G259R E260K |
Mutation Type | NSF: non-susceptible form |
Method | CD8 T-cell Elispot - IFNy, Tetramer binding |
Note | None of the patients tested responded to this variant. |
Variant ID. | 1807 |
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Epitope Seq. | GEIYKRWII |
Variant Seq. | GdIYrkWIv |
Mutations | E/D K/R R/K I/V |
Epitope Location | E2D K5R R6K I9V |
HXB2 Location | E260D K263R R264K I267V |
Mutation Type | NSF: non-susceptible form |
Method | CD8 T-cell Elispot - IFNy, Tetramer binding |
Note | None of the patients tested responded well to this variant. |
Variant ID. | 1808 |
---|---|
Epitope Seq. | GEIYKRWII |
Variant Seq. | GnIYrRWIq |
Mutations | E/N K/R I/Q |
Epitope Location | E2N K5R I9Q |
HXB2 Location | E260N K263R I267Q |
Mutation Type | NSF: non-susceptible form |
Method | CD8 T-cell Elispot - IFNy, Tetramer binding |
Note | None of the patients tested responded to this variant. |
Variant ID. | 1809 |
---|---|
Epitope Seq. | GEIYKRWII |
Variant Seq. | GEIYKRWIv |
Mutations | I/V |
Epitope Location | I9V |
HXB2 Location | I267V |
Mutation Type | DR: diminished response SF: susceptible form |
Method | CD8 T-cell Elispot - IFNy, Tetramer binding |
Note | Some patients had response at the level of the response to the index peptide. 2 patients had about 50% of the original response. |
Variant ID. | 1810 |
---|---|
Epitope Seq. | GEIYKRWII |
Variant Seq. | GdIYKRWII |
Mutations | E/D |
Epitope Location | E2D |
HXB2 Location | E260D |
Mutation Type | DR: diminished response SF: susceptible form |
Method | CD8 T-cell Elispot - IFNy, Tetramer binding |
Note | Some patients had response at the level of the response to the index peptide. 2 patients had about 50% of the original response. |
Variant ID. | 1811 |
---|---|
Epitope Seq. | GEIYKRWII |
Variant Seq. | GdIYKRWIv |
Mutations | E/D I/V |
Epitope Location | E2D I9V |
HXB2 Location | E260D I267V |
Mutation Type | DR: diminished response NSF: non-susceptible form SF: susceptible form |
Method | CD8 T-cell Elispot - IFNy, Tetramer binding |
Note | One patient responded at 80% of original response, 2 at 60%, 1 at 40% and 1 at 10%. |
Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.
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