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Found 1 matching record:

Displaying record number 55002

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
raPRTLNAW   non-susceptible form
mSPRTLNAW   non-susceptible form; susceptible form
vSPRTLNAW   non-susceptible form; susceptible form
ltPRTLNAW   non-susceptible form; susceptible form
vtPRTLNAW   non-susceptible form; susceptible form
ISaRTLNAW   non-susceptible form; susceptible form
IaPRTLNAr   non-susceptible form
lSPRTLNAW   diminished response; susceptible form
Epitope Name ISP
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 8 variant(s).


Variant ID.  1789
Epitope Seq.  ISPRTLNAW
Variant Seq.  raPRTLNAW
Mutations I/R S/A
Epitope Location I1R S2A
HXB2 Location I147R S148A
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note None of the patients tested recognized the variant.


Variant ID.  1790
Epitope Seq.  ISPRTLNAW
Variant Seq.  mSPRTLNAW
Mutations I/M
Epitope Location I1M
HXB2 Location I147M
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note Some patients recognized the variant, some did not.


Variant ID.  1791
Epitope Seq.  ISPRTLNAW
Variant Seq.  vSPRTLNAW
Mutations I/V
Epitope Location I1V
HXB2 Location I147V
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note Some patients recognized the variant, some did not.


Variant ID.  1792
Epitope Seq.  ISPRTLNAW
Variant Seq.  ltPRTLNAW
Mutations I/L S/T
Epitope Location I1L S2T
HXB2 Location I147L S148T
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note Some patients recognized the variant, some did not.


Variant ID.  1793
Epitope Seq.  ISPRTLNAW
Variant Seq.  vtPRTLNAW
Mutations I/V S/T
Epitope Location I1V S2T
HXB2 Location I147V S148T
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note Some patients recognized the variant, some did not.


Variant ID.  1794
Epitope Seq.  ISPRTLNAW
Variant Seq.  ISaRTLNAW
Mutations P/A
Epitope Location P3A
HXB2 Location P149A
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note Some patients recognized the variant, some did not.


Variant ID.  1795
Epitope Seq.  ISPRTLNAW
Variant Seq.  IaPRTLNAr
Mutations S/A W/R
Epitope Location S2A W9R
HXB2 Location S148A W155R
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note None of the patients tested recognized the variant.


Variant ID.  1796
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type DR: diminished response
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note Some patients recognized the variant at the level of the index peptide, some had diminished response.

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


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