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Found 1 matching record:

Displaying record number 54662

HXB2 Location  Pol(63-72)   Pol Epitope Map
View variants at this location
Epitope QRPLVTVKIG   Epitope Alignment
Variants
QRPiVTVKIG   drug induced; escape documented in this paper
QRPLVTVrIG   HLA association; drug induced
Epitope Name QG10
Species (MHC/HLA human(B51)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1319
Epitope Seq.  QRPLVTVKIG
Variant Seq.  QRPiVTVKIG
Mutations L/I
Epitope Location L4I
HXB2 Location L66I
Mutation Type DI: drug induced
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Sequence
Note This is a drug-induced polymorphism that results in impaired CTL responses.


Variant ID.  1320
Epitope Seq.  QRPLVTVKIG
Variant Seq.  QRPLVTVrIG
Mutations K/R
Epitope Location K8R
HXB2 Location K70R
Mutation Type A: HLA association
DI: drug induced
Method CD8 T-cell Elispot - IFNy, Sequence
Note This atazanavir-induced minor mutation, K14R, is associated with the broad antigen HLA-B5.

References

Mueller2007 Sandra M. Mueller, Birgit Schaetz, Kathrin Eismann, Silke Bergmann, Michael Bauerle, Matthias Schmitt-Haendle, Hauke Walter, Barbara Schmidt, Klaus Korn, Heinrich Sticht, Bernd Spriewald, Ellen G. Harrer, and Thomas Harrer. Dual Selection Pressure by Drugs and HLA Class I-Restricted Immune Responses on Human Immunodeficiency Virus Type 1 Protease. J. Virol., 81(6):2887-2898, Mar 2007. PubMed ID: 17202219. Show all entries for this paper.


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