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Displaying record number 54657

HXB2 Location  Pol(101-110)   Pol Epitope Map
View variants at this location
Epitope KMIGGIGGFI   Epitope Alignment
Variants
KiIGGIGGFI   drug induced; escape documented in this paper; susceptible form
KMIGGIGGFv   drug induced; escape documented in this paper; susceptible form
Epitope Name KI10
Species (MHC/HLA human(A2, B62)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1328
Epitope Seq.  KMIGGIGGFI
Variant Seq.  KiIGGIGGFI
Mutations M/I
Epitope Location M2I
HXB2 Location M102I
Mutation Type DI: drug induced
E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note PBMC from HLA-A2 and HLA-B62-positive patients were stimulated with the index peptide KMIGGIGGFI and the tipranavir and atazanavir induced variants KiIGGIGGFI and KMIGGIGGFv, and evaluated for cross recognition. In samples from some A2-positive patients CD8+-T-cell recognition was abolished by these mutations, whereas in samples from other A2-positive patients a CD8+-T-cell response was induced only by the mutant peptides.


Variant ID.  1329
Epitope Seq.  KMIGGIGGFI
Variant Seq.  KMIGGIGGFv
Mutations I/V
Epitope Location I10V
HXB2 Location I110V
Mutation Type DI: drug induced
E: escape documented in this paper
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note PBMC from HLA-A2 and HLA-B62-positive patients were stimulated with the index peptide KMIGGIGGFI and the tipranavir and atazanavir induced variants KiIGGIGGFI and KMIGGIGGFv, and evaluated for cross recognition. In samples from some A2-positive patients CD8+-T-cell recognition was abolished by these mutations, whereas in samples from other A2-positive patients a CD8+-T-cell response was induced only by the mutant peptides.

References

Mueller2007 Sandra M. Mueller, Birgit Schaetz, Kathrin Eismann, Silke Bergmann, Michael Bauerle, Matthias Schmitt-Haendle, Hauke Walter, Barbara Schmidt, Klaus Korn, Heinrich Sticht, Bernd Spriewald, Ellen G. Harrer, and Thomas Harrer. Dual Selection Pressure by Drugs and HLA Class I-Restricted Immune Responses on Human Immunodeficiency Virus Type 1 Protease. J. Virol., 81(6):2887-2898, Mar 2007. PubMed ID: 17202219. Show all entries for this paper.


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