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Displaying record number 54657

HXB2 Location Pol(101-110) Pol Epitope Map
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KMIGGIGGFI

`KiIGGIGGFI`		drug induced; escape documented in this paper; susceptible form
`KMIGGIGGFv`		drug induced; escape documented in this paper; susceptible form

Epitope Name KI10

Species (MHC/HLA) human(A2, B62)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1328`
Epitope Seq.	`KMIGGIGGFI`
Variant Seq.	`KiIGGIGGFI`
Mutations	M/I
Epitope Location	M2I
HXB2 Location	M102I
Mutation Type	DI: drug induced E: escape documented in this paper SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	PBMC from HLA-A2 and HLA-B62-positive patients were stimulated with the index peptide KMIGGIGGFI and the tipranavir and atazanavir induced variants KiIGGIGGFI and KMIGGIGGFv, and evaluated for cross recognition. In samples from some A2-positive patients CD8+-T-cell recognition was abolished by these mutations, whereas in samples from other A2-positive patients a CD8+-T-cell response was induced only by the mutant peptides.

Variant ID.	`1329`
Epitope Seq.	`KMIGGIGGFI`
Variant Seq.	`KMIGGIGGFv`
Mutations	I/V
Epitope Location	I10V
HXB2 Location	I110V
Mutation Type	DI: drug induced E: escape documented in this paper SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	PBMC from HLA-A2 and HLA-B62-positive patients were stimulated with the index peptide KMIGGIGGFI and the tipranavir and atazanavir induced variants KiIGGIGGFI and KMIGGIGGFv, and evaluated for cross recognition. In samples from some A2-positive patients CD8+-T-cell recognition was abolished by these mutations, whereas in samples from other A2-positive patients a CD8+-T-cell response was induced only by the mutant peptides.

References

Mueller2007 Sandra M. Mueller, Birgit Schaetz, Kathrin Eismann, Silke Bergmann, Michael Bauerle, Matthias Schmitt-Haendle, Hauke Walter, Barbara Schmidt, Klaus Korn, Heinrich Sticht, Bernd Spriewald, Ellen G. Harrer, and Thomas Harrer. Dual Selection Pressure by Drugs and HLA Class I-Restricted Immune Responses on Human Immunodeficiency Virus Type 1 Protease. J. Virol., 81(6):2887-2898, Mar 2007. PubMed ID: 17202219. Show all entries for this paper.