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Found 1 matching record:

Displaying record number 54624

HXB2 Location  Nef(71-79)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPM   Epitope Alignment
Variants
RPQVPvRPM   calculated escape
RPQVPtRPM   observed variant
RPQVPmRPM   observed variant
RPQmPLRPM   observed variant
kPQVPvRPM   observed variant
RPQVPiRPM   observed variant
tPQVPIRPM   observed variant
Epitope Name RM9
Species (MHC/HLA human(B*8101)

Variant Details

Showing all: 7 variant(s).


Variant ID.  272
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPvRPM
Mutations L/V
Epitope Location L6V
HXB2 Location L76V
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*8101 patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.


Variant ID.  273
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPtRPM
Mutations L/T
Epitope Location L6T
HXB2 Location L76T
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  274
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPmRPM
Mutations L/M
Epitope Location L6M
HXB2 Location L76M
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  275
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQmPLRPM
Mutations V/M
Epitope Location V4M
HXB2 Location V74M
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  276
Epitope Seq.  RPQVPLRPM
Variant Seq.  kPQVPvRPM
Mutations R/K L/V
Epitope Location R1K L6V
HXB2 Location R71K L76V
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  277
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPiRPM
Mutations L/I
Epitope Location L6I
HXB2 Location L76I
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  278
Epitope Seq.  RPQVPLRPM
Variant Seq.  tPQVPIRPM
Mutations R/T L/I
Epitope Location R1T L6I
HXB2 Location R71T L76I
Mutation Type OV: observed variant
Note Found in African cohort

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. G√ľnthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


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