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Displaying record number 54618

HXB2 Location Gag(263-272) Gag Epitope Map
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KRWIILGLNK

`KkWIILGLNK`		calculated escape
`KRWIImGLNK`		calculated escape
`KRWvImGLNK`		observed variant
`KkWIImGLNK`		observed variant
`KRWIIiGLNK`		calculated escape

Epitope Name KK10

Species (MHC/HLA) human(B*27)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`254`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KkWIILGLNK`
Mutations	R/K
Epitope Location	R2K
HXB2 Location	R264K
Mutation Type	CE: calculated escape
Note	The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.

Variant ID.	`255`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	CE: calculated escape
Note	The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. Leucine at position 6 was under strong positive selection pressure.

Variant ID.	`256`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWvImGLNK`
Mutations	I/V L/M
Epitope Location	I4V L6M
HXB2 Location	I266V L268M
Mutation Type	OV: observed variant
Note	Found in European cohort

Variant ID.	`257`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KkWIImGLNK`
Mutations	R/K L/M
Epitope Location	R2K L6M
HXB2 Location	R264K L268M
Mutation Type	OV: observed variant
Note	Found in European cohort

Variant ID.	`258`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIIiGLNK`
Mutations	L/I
Epitope Location	L6I
HXB2 Location	L268I
Mutation Type	CE: calculated escape
Note	The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. Leucine at position 6 was under strong positive selection pressure.

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.