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Found 1 matching record:

Displaying record number 54618

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KkWIILGLNK   calculated escape
KRWIImGLNK   calculated escape
KRWvImGLNK   observed variant
KkWIImGLNK   observed variant
KRWIIiGLNK   calculated escape
Epitope Name KK10
Species (MHC/HLA human(B*27)

Variant Details

Showing all: 5 variant(s).


Variant ID.  254
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type CE: calculated escape
Note The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.


Variant ID.  255
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type CE: calculated escape
Note The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. Leucine at position 6 was under strong positive selection pressure.


Variant ID.  256
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWvImGLNK
Mutations I/V L/M
Epitope Location I4V L6M
HXB2 Location I266V L268M
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  257
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  258
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIiGLNK
Mutations L/I
Epitope Location L6I
HXB2 Location L268I
Mutation Type CE: calculated escape
Note The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. Leucine at position 6 was under strong positive selection pressure.

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


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