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Displaying record number 54617

HXB2 Location Pol(283-290) Pol Epitope Map
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TAFTIPSI

`TAFTIPSt`		calculated escape
`TAFTIPSm`		observed variant
`TAFTIPSr`		observed variant
`TAFTvPSt`		observed variant

Epitope Name TI8

Species (MHC/HLA) human(B*51)

Variant Details

Showing all: 4 variant(s).

Variant ID.	`268`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSt`
Mutations	I/T
Epitope Location	I8T
HXB2 Location	I290T
Mutation Type	CE: calculated escape
Note	The variant appears very soon after seroconversion, and was present in 7/8 HLA-matched and 21/57 HLA-unmatched patients. Position 8 was under strong positive selection pressure.

Variant ID.	`269`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSm`
Mutations	I/M
Epitope Location	I8M
HXB2 Location	I290M
Mutation Type	OV: observed variant
Note	Found in European cohort

Variant ID.	`270`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSr`
Mutations	I/R
Epitope Location	I8R
HXB2 Location	I290R
Mutation Type	OV: observed variant
Note	Found in European cohort

Variant ID.	`271`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTvPSt`
Mutations	I/V I/T
Epitope Location	I5V I8T
HXB2 Location	I287V I290T
Mutation Type	OV: observed variant
Note	Found in European cohort

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.