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Found 1 matching record:

Displaying record number 54617

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   calculated escape
TAFTIPSm   observed variant
TAFTIPSr   observed variant
TAFTvPSt   observed variant
Epitope Name TI8
Species (MHC/HLA human(B*51)

Variant Details

Showing all: 4 variant(s).


Variant ID.  268
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type CE: calculated escape
Note The variant appears very soon after seroconversion, and was present in 7/8 HLA-matched and 21/57 HLA-unmatched patients. Position 8 was under strong positive selection pressure.


Variant ID.  269
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSm
Mutations I/M
Epitope Location I8M
HXB2 Location I290M
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  270
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  271
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTvPSt
Mutations I/V I/T
Epitope Location I5V I8T
HXB2 Location I287V I290T
Mutation Type OV: observed variant
Note Found in European cohort

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


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