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Found 1 matching record:

Displaying record number 54581

HXB2 Location  Nef(183-191)   Nef Epitope Map
View variants at this location
Epitope WRFDSRLAF   Epitope Alignment
Variants
WkFDSRLAF   susceptible form
WRFgSRLAF   inferred escape
WRFDSsLAF   inferred escape
WRFDSRLAc   inferred escape
WRFDSRLAl   inferred escape
Epitope Name WF9
Species (MHC/HLA human(B*15)

Variant Details

Showing all: 5 variant(s).


Variant ID.  665
Epitope Seq.  WRFDSRLAF
Variant Seq.  WkFDSRLAF
Mutations R/K
Epitope Location R2K
HXB2 Location R184K
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Variant found at week 158 in 4/14 clones. Variant elicited a potent HLA-B15 restricted immune response.


Variant ID.  666
Epitope Seq.  WRFDSRLAF
Variant Seq.  WRFgSRLAF
Mutations D/G
Epitope Location D4G
HXB2 Location D186G
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 13 in 1/26 clones from patient OP177 as viral escape. No CTL response detected against the variant.


Variant ID.  667
Epitope Seq.  WRFDSRLAF
Variant Seq.  WRFDSsLAF
Mutations R/S
Epitope Location R6S
HXB2 Location R188S
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 10 in 2/16 clones from patient OP177 as viral escape. No CTL response detected against the variant.


Variant ID.  668
Epitope Seq.  WRFDSRLAF
Variant Seq.  WRFDSRLAc
Mutations F/C
Epitope Location F9C
HXB2 Location F191C
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 13 in 1/26 clones from patient OP177 as viral escape. No CTL response detected against the variant.


Variant ID.  669
Epitope Seq.  WRFDSRLAF
Variant Seq.  WRFDSRLAl
Mutations F/L
Epitope Location F9L
HXB2 Location F191L
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 13 in 1/26 clones from patient OP177 as viral escape. No CTL response detected against the variant.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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