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Found 1 matching record:

Displaying record number 54579

HXB2 Location  Gag(93-101)   Gag Epitope Map
View variants at this location
Epitope EVKDTKEAL   Epitope Alignment
Variants
dVKDTKEAL   diminished response
EiKDTKEAL   inferred escape
kVKDTKEAL   inferred escape
EVKDTKgAL   inferred escape
Epitope Name EL9
Species (MHC/HLA human(B*08)

Variant Details

Showing all: 4 variant(s).


Variant ID.  637
Epitope Seq.  EVKDTKEAL
Variant Seq.  dVKDTKEAL
Mutations E/D
Epitope Location E1D
HXB2 Location E93D
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Variant found in one patient at week 63. A minor response to this variant, but the variant was eliminated by CTLs. R91G upstream mutation affects processing.


Variant ID.  638
Epitope Seq.  EVKDTKEAL
Variant Seq.  EiKDTKEAL
Mutations V/I
Epitope Location V2I
HXB2 Location V94I
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant detected in 9/14 clones at week 39 in patient OP428 as viral escape. No CTL response detected.


Variant ID.  639
Epitope Seq.  EVKDTKEAL
Variant Seq.  kVKDTKEAL
Mutations E/K
Epitope Location E1K
HXB2 Location E93K
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant detected in 1/11 clones at week 139 in patient OP428 as viral escape. No CTL response detected.


Variant ID.  640
Epitope Seq.  EVKDTKEAL
Variant Seq.  EVKDTKgAL
Mutations E/G
Epitope Location E7G
HXB2 Location E99G
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant detected in 1/16 clones at week 15 in patient OP428 as viral escape. No CTL response detected.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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