HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Nef(92-100) | Nef Epitope Map
View variants at this location |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Epitope |
KEKGGLEGL
|
Epitope Alignment | |||||||
| Variants |
|
||||||||
| Epitope Name | KL9 | ||||||||
| Species (MHC/HLA) | human(B*40) | ||||||||
Showing all: 2 variant(s).
| Variant ID. | 660 |
|---|---|
| Epitope Seq. | KEKGGLEGL |
| Variant Seq. | KEKGGLdGL |
| Mutations | E/D |
| Epitope Location | E7D |
| HXB2 Location | E98D |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Variant found at weeks 109 and 158. A less intense CTL response targeted this variant than the wt epitope. |
| Variant ID. | 661 |
|---|---|
| Epitope Seq. | KEKGGLEGL |
| Variant Seq. | KEKGGLEeL |
| Mutations | G/E |
| Epitope Location | G8E |
| HXB2 Location | G99E |
| Mutation Type | IE: inferred escape |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Author tabulates this variant found at week 158 in 1/14 clones as viral escape. No CTL response detected against the variant. |
Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.