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Found 1 matching record:

Displaying record number 54578

HXB2 Location  Nef(92-100)   Nef Epitope Map
View variants at this location
Epitope KEKGGLEGL   Epitope Alignment
Variants
KEKGGLdGL   diminished response
KEKGGLEeL   inferred escape
Epitope Name KL9
Species (MHC/HLA human(B*40)

Variant Details

Showing all: 2 variant(s).


Variant ID.  660
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLdGL
Mutations E/D
Epitope Location E7D
HXB2 Location E98D
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Variant found at weeks 109 and 158. A less intense CTL response targeted this variant than the wt epitope.


Variant ID.  661
Epitope Seq.  KEKGGLEGL
Variant Seq.  KEKGGLEeL
Mutations G/E
Epitope Location G8E
HXB2 Location G99E
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 158 in 1/14 clones as viral escape. No CTL response detected against the variant.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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