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Found 1 matching record:

Displaying record number 54570

HXB2 Location  Pol(188-196)   Pol Epitope Map
View variants at this location
Epitope ALVEICTEM   Epitope Alignment
Variants
ALiEICTEM   diminished response
ALmEICTEM   susceptible form
ALtEICTEM   observed variant
ALiEICTEt   observed variant
ALiEICTdM   observed variant
ALmkICTEM   observed variant
ALmEICaEM   observed variant
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 7 variant(s).


Variant ID.  642
Epitope Seq.  ALVEICTEM
Variant Seq.  ALiEICTEM
Mutations V/I
Epitope Location V3I
HXB2 Location V190I
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Weaker responses to this variant. Variant found at the start of infection.


Variant ID.  643
Epitope Seq.  ALVEICTEM
Variant Seq.  ALmEICTEM
Mutations V/M
Epitope Location V3M
HXB2 Location V190M
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Strongest responses to this variant that emerged after the first variant. Eventually it reverted back to the wt sequence.


Variant ID.  644
Epitope Seq.  ALVEICTEM
Variant Seq.  ALtEICTEM
Mutations V/T
Epitope Location V3T
HXB2 Location V190T
Mutation Type OV: observed variant
Note Variant found in 1/17 clones at week 39.


Variant ID.  645
Epitope Seq.  ALVEICTEM
Variant Seq.  ALiEICTEt
Mutations V/I M/T
Epitope Location V3I M9T
HXB2 Location V190I M196T
Mutation Type OV: observed variant
Note Variant found in 1/17 clones at week 39.


Variant ID.  646
Epitope Seq.  ALVEICTEM
Variant Seq.  ALiEICTdM
Mutations V/I E/D
Epitope Location V3I E8D
HXB2 Location V190I E195D
Mutation Type OV: observed variant
Note Variant found in 1/12 clones at week 88.


Variant ID.  647
Epitope Seq.  ALVEICTEM
Variant Seq.  ALmkICTEM
Mutations V/M E/K
Epitope Location V3M E4K
HXB2 Location V190M E191K
Mutation Type OV: observed variant
Note Variant found in 1/12 clones at week 88.


Variant ID.  648
Epitope Seq.  ALVEICTEM
Variant Seq.  ALmEICaEM
Mutations V/M T/A
Epitope Location V3M T7A
HXB2 Location V190M T194A
Mutation Type OV: observed variant
Note Variant found in 1/13 clones at week 156.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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