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Found 1 matching record:

Displaying record number 54566

HXB2 Location  Nef(180-189)   Nef Epitope Map
View variants at this location
Epitope VLEWRFDSRL   Epitope Alignment
Variants
VLEWRFDSsL   inferred escape
VLEWRFgSRL   inferred escape
VLEWkFDSRL   diminished response
Epitope Name VL10
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 3 variant(s).


Variant ID.  662
Epitope Seq.  VLEWRFDSRL
Variant Seq.  VLEWRFDSsL
Mutations R/S
Epitope Location R9S
HXB2 Location R188S
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 10 in 2/16 clones from patient OP177 as viral escape. No CTL response detected against the variant.


Variant ID.  663
Epitope Seq.  VLEWRFDSRL
Variant Seq.  VLEWRFgSRL
Mutations D/G
Epitope Location D7G
HXB2 Location D186G
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 13 in 1/26 clones from patient OP177 as viral escape. No CTL response detected against the variant.


Variant ID.  664
Epitope Seq.  VLEWRFDSRL
Variant Seq.  VLEWkFDSRL
Mutations R/K
Epitope Location R5K
HXB2 Location R184K
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Variant found at week 158 in 4/14 clones. A less intense CTL response targeted this variant than the wt epitope.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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