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Displaying record number 54564

HXB2 Location  Nef(83-91)   Nef Epitope Map
View variants at this location
Epitope AAVDLSHFL   Epitope Alignment
Variants
AAVDiSHFL   diminished response
AAVDirHFL   inferred escape
gAlDLSHFL   diminished response; escape documented in this paper
gArDLSHFL   escape documented in this paper
gAfDLSfFL   escape documented in this paper
AAlDLSHFL   escape documented in this paper
AAiDLSHFL   escape documented in this paper
AAlDiSHFL   diminished response
AAlDiSHlL   inferred escape
kAlDLSHFL   inferred escape
gAVDLSHFL   escape documented in this paper
Epitope Name AL9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 11 variant(s).


Variant ID.  649
Epitope Seq.  AAVDLSHFL
Variant Seq.  AAVDiSHFL
Mutations L/I
Epitope Location L5I
HXB2 Location L87I
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Variant found as a minor population at week 10 (5/16 clones) and dominated viral population at later timepoint. A less intense CTL response targeted this variant than the wt epitope and an increase in viral load was observed. Position under positive selection.


Variant ID.  650
Epitope Seq.  AAVDLSHFL
Variant Seq.  AAVDirHFL
Mutations L/I S/R
Epitope Location L5I S6R
HXB2 Location L87I S88R
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 61 in 1/14 clones from patient OP177 as viral escape. No CTL response detected against the variant.


Variant ID.  651
Epitope Seq.  AAVDLSHFL
Variant Seq.  gAlDLSHFL
Mutations A/G V/L
Epitope Location A1G V3L
HXB2 Location A83G V85L
Mutation Type DR: diminished response
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant found as a major population at week 158 in one of the patients, and a less prevalent CTL response against it could be detected. Positions under positive selection. Variant was found in many of the HLA-A2 positive and HLA-A2 negative patients at baseline and follow up timepoints. None of the patients were able to generate a CTL response against autologous virus.


Variant ID.  652
Epitope Seq.  AAVDLSHFL
Variant Seq.  gArDLSHFL
Mutations A/G V/R
Epitope Location A1G V3R
HXB2 Location A83G V85R
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant was found in one of the HLA-A2 positive patients at baseline and follow up timepoints. The patient was not able to generate a CTL response against autologous virus.


Variant ID.  653
Epitope Seq.  AAVDLSHFL
Variant Seq.  gAfDLSfFL
Mutations A/G V/F H/F
Epitope Location A1G V3F H7F
HXB2 Location A83G V85F H89F
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant was found in one of the HLA-A2 negative patients at baseline and follow up timepoints. The patient was not able to generate a CTL response against autologous virus.


Variant ID.  654
Epitope Seq.  AAVDLSHFL
Variant Seq.  AAlDLSHFL
Mutations V/L
Epitope Location V3L
HXB2 Location V85L
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant found at week 109 in 1/13 clones in one of the patients. No CTL response detected against the variant. Variant was also found in two HLA-A2 negative patients at baseline and follow up timepoints. None of the patients were able to generate a CTL response against autologous virus.


Variant ID.  655
Epitope Seq.  AAVDLSHFL
Variant Seq.  AAiDLSHFL
Mutations V/I
Epitope Location V3I
HXB2 Location V85I
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant was found in one of the HLA-A2 negative patients at baseline and follow up timepoints. The patient was not able to generate a CTL response against autologous virus.


Variant ID.  656
Epitope Seq.  AAVDLSHFL
Variant Seq.  AAlDiSHFL
Mutations V/L L/I
Epitope Location V3L L5I
HXB2 Location V85L L87I
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Variant found at weeks 109 and 158. A less intense CTL response targeted this variant than the wt epitope and an increase in viral load was observed.


Variant ID.  657
Epitope Seq.  AAVDLSHFL
Variant Seq.  AAlDiSHlL
Mutations V/L L/I F/L
Epitope Location V3L L5I F8L
HXB2 Location V85L L87I F90L
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 109 in 1/13 clones in patient OP177 as viral escape. No CTL response detected against the variant.


Variant ID.  658
Epitope Seq.  AAVDLSHFL
Variant Seq.  kAlDLSHFL
Mutations A/K V/L
Epitope Location A1K V3L
HXB2 Location A83K V85L
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant found at week 109 in 1/13 clones from patient OP177 as viral escape. No CTL response detected against the variant.


Variant ID.  659
Epitope Seq.  AAVDLSHFL
Variant Seq.  gAVDLSHFL
Mutations A/G
Epitope Location A1G
HXB2 Location A83G
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant found in two HLA-A2 positive patients at baseline timepoint and none of the patients were able to generate a CTL response against autologous virus.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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