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Displaying record number 54556

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiATL   susceptible form
SLfNTiATL   diminished response; escape documented in this paper
SLYNaiATL   inferred escape
SLcNTiATL   inferred escape
Epitope Name SL9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 4 variant(s).


Variant ID.  633
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note A major variant detected by week 39 in one of the patients that induced a CTL response.


Variant ID.  634
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type DR: diminished response
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant detected by week 63. Lower magnitude responses than wt and V/I mutant. Positive selection. Seen with upstream changes E62G/V/A, where the 62A mutation persisted and is suggested to reduce fitness cost of the Y/F escape mutation.


Variant ID.  635
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNaiATL
Mutations T/A V/I
Epitope Location T5A V6I
HXB2 Location T81A V82I
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant detected in 1/14 clones at week 39 in patients. OP428 as viral escape. No CTL response detected.


Variant ID.  636
Epitope Seq.  SLYNTVATL
Variant Seq.  SLcNTiATL
Mutations Y/C V/I
Epitope Location Y3C V6I
HXB2 Location Y79C V82I
Mutation Type IE: inferred escape
Method CD8 T-cell Elispot - IFNy
Note Author tabulates this variant as a viral escape, detected in 1/12 clones at week 63 in patient OP428. No CTL response detected.

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


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