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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Displaying record number 54216

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLaEQIaW   observed variant
TSnLQEQIaW   escape documented in this paper
TSnLQEQItW   observed variant
TSnLQEQIqW   observed variant
TSnLsEQIaW   observed variant
TSnLQEQvaW   observed variant
TtnLQEQIaW   observed variant
TSThQEQIaW   observed variant
TSTLQEQIaW   diminished response
TSTLQEQIdW   observed variant
TSTLpEQIGW   observed variant
TSnLQEQIGW   escape documented in this paper; reversion; replicative capacity reduced
Epitope Name TW10
Species (MHC/HLA human(B*57, B*58:01)

Variant Details

Showing all: 12 variant(s).


Variant ID.  1070
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLaEQIaW
Mutations T/N Q/A G/A
Epitope Location T3N Q5A G9A
HXB2 Location T242N Q244A G248A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This triple variant was found in 1/80 HLA-B*57/58 subjects infected by Clade B HIV-1, and in 0/239 HLA-B*57/5801 negative subjects.


Variant ID.  1071
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIaW
Mutations T/N G/A
Epitope Location T3N G9A
HXB2 Location T242N G248A
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Previously reported in the literature, Sequence
Note This previously suggested escape, a double variant was found in 30/80 HLA-B*57/58 subjects infected by Clade B HIV-1, but only in 1/239 HLA-B*57/5801 negative subjects. It abrogates recognition completely at low peptide concentrations.


Variant ID.  1072
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQItW
Mutations T/N G/T
Epitope Location T3N G9T
HXB2 Location T242N G248T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This double variant was found in 4/80 HLA-B*57/58 subjects, but in none of 107 HLA-B*57/5801 negative subjects infected with Clade B HIV-1.


Variant ID.  1073
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIqW
Mutations T/N G/Q
Epitope Location T3N G9Q
HXB2 Location T242N G248Q
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This double variant was found in 3/80 HLA-B*57/58 subjects infected with Clade B HIV-1, but in no HLA-B*57/5801 negative subjects.


Variant ID.  1074
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLsEQIaW
Mutations T/N Q/S G/A
Epitope Location T3N Q5S G9A
HXB2 Location T242N Q244S G248A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This triple variant was found in 1/80 HLA-B*57/58 subjects infected with Clade B HIV-1, and in no HLA-B*57/5801 negative subjects.


Variant ID.  1075
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQvaW
Mutations T/N I/V G/A
Epitope Location T3N I8V G9A
HXB2 Location T242N I247V G248A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This triple variant was found in 1/80 HLA-B*57/58 subjects infected with Clade B HIV-1, and in no HLA-B*57/5801 negative subjects.


Variant ID.  1076
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TtnLQEQIaW
Mutations S/T T/N G/A
Epitope Location S2T T3N G9A
HXB2 Location S241T T242N G248A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This triple variant was found in 1/80 HLA-B*57/58 subjects infected with Clade B HIV-1, and in no HLA-B*57/5801 negative subjects.


Variant ID.  1077
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSThQEQIaW
Mutations L/H G/A
Epitope Location L4H G9A
HXB2 Location L243H G248A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This double variant was found in 1/80 HLA-B*57/58 subjects infected with Clade B HIV-1, and in no HLA-B*57/5801 negative subjects.


Variant ID.  1078
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Previously reported in the literature, Sequence
Note This variant was found in 6/80 HLA-B*57/58 subjects, but only in 17/107 HLA-B*57/5801 negative subjects infected with Clade B HIV-1. It arises commonly and at no cost to the virus and is readily transmitted to persistence in restricting HLA negative subjects, is not correlated with compensations and increases viral infectivity. It is however, relatively ineffective as an escape with only partial loss of recognition.


Variant ID.  1079
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIdW
Mutations G/D
Epitope Location G9D
HXB2 Location G248D
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This variant was found in 1/68 HLA-B*57 subjects, and in 0/107 HLA-B*57/5801 negative subjects infected with Clade B HIV-1.


Variant ID.  1080
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLpEQIGW
Mutations Q/P
Epitope Location Q5P
HXB2 Location Q244P
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This variant was found in 1/80 HLA-B*57/58 subjects, and in no HLA-B*57/5801 negative subjects infected with Clade B HIV-1.


Variant ID.  1081
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type E: escape documented in this paper
R: reversion
RCR: replicative capacity reduced
Epitope Subtype B, C
Variant Subtype B, C
Note This T242N variant from Clade B consensus was found in 24/80 HLA-B*57/5801 subjects, but only in 1/107 HLA-B*57/5801 negative subject infected with Clade B HIV-1. T242N from Clade C consensus was found in 68/126 HLA-B*57/5801 subjects, but only in 2/132 HLA-B*57/5801 negative subjects infected with Clade C HIV-1. It was thought to revert quickly to TSTLQEQIAW in HLA-B*57/5801 negative subjects since viral replication is affected in these mutants. Amino acid T at position Gag242 is the helix stabilizing residue in p24 Gag.

References

Martinez-Picado2006 Javier Martinez-Picado, Julia G. Prado, Elizabeth E. Fry, Katja Pfafferott, Alasdair Leslie, Senica Chetty, Christina Thobakgale, Isobel Honeyborne, Hayley Crawford, Philippa Matthews, Tilly Pillay, Christine Rousseau, James I. Mullins, Christian Brander, Bruce D. Walker, David I. Stuart, Photini Kiepiela, and Philip Goulder. Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1. J. Virol., 80(7):3617-3623, Apr 2006. PubMed ID: 16537629. Show all entries for this paper.


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