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Found 1 matching record:

Displaying record number 54168

HXB2 Location  Nef(5-13)   Nef Epitope Map
View variants at this location
Epitope WSKSSIIGW   Epitope Alignment
Variants
WSKtSIIGW   escape documented in this paper
WSKSSmIGW   escape documented in this paper
Epitope Name WW9
Species (MHC/HLA human(A*25:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  995
Epitope Seq.  WSKSSIIGW
Variant Seq.  WSKtSIIGW
Mutations S/T
Epitope Location S4T
HXB2 Location S8T
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Positions 4 and 6 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.


Variant ID.  996
Epitope Seq.  WSKSSIIGW
Variant Seq.  WSKSSmIGW
Mutations I/M
Epitope Location I6M
HXB2 Location I10M
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Positions 4 and 6 in the epitope had potentially experienced positive selection. The variant was full escape, as it was not recognized by CTLs.

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


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