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Found 1 matching record:

Displaying record number 54161

HXB2 Location  gp160(61-69)   gp160 Epitope Map
View variants at this location
Epitope YETEVHNVW   Epitope Alignment
Variants
YgTEVHNVW   diminished response
YdTEVHNVW   diminished response
YETEaHNVW   susceptible form
YdTEaHNVW   diminished response
Epitope Name YW9
Species (MHC/HLA human(B*18:01)

Variant Details

Showing all: 4 variant(s).


Variant ID.  981
Epitope Seq.  YETEVHNVW
Variant Seq.  YgTEVHNVW
Mutations E/G
Epitope Location E2G
HXB2 Location E62G
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was 22 times better recognized than the variant, making the variant a partial escape.


Variant ID.  982
Epitope Seq.  YETEVHNVW
Variant Seq.  YdTEVHNVW
Mutations E/D
Epitope Location E2D
HXB2 Location E62D
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was 13 times better recognized than the variant, making the variant a partial escape.


Variant ID.  983
Epitope Seq.  YETEVHNVW
Variant Seq.  YETEaHNVW
Mutations V/A
Epitope Location V5A
HXB2 Location V65A
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Positions 2 and 5 in the epitope had potentially experienced positive selection. The variant was recognized by CTLs to a similar extent as the wt form of the epitope.


Variant ID.  984
Epitope Seq.  YETEVHNVW
Variant Seq.  YdTEaHNVW
Mutations E/D V/A
Epitope Location E2D V5A
HXB2 Location E62D V65A
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was >83 times better recognized than the variant, making the variant a partial escape.

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


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