HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | gp160(61-69) | gp160 Epitope Map
View variants at this location |
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| Epitope |
YETEVHNVW
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Epitope Alignment | |||||||||||||
| Variants |
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| Epitope Name | YW9 | ||||||||||||||
| Species (MHC/HLA) | human(B*18:01) | ||||||||||||||
Showing all: 4 variant(s).
| Variant ID. | 981 |
|---|---|
| Epitope Seq. | YETEVHNVW |
| Variant Seq. | YgTEVHNVW |
| Mutations | E/G |
| Epitope Location | E2G |
| HXB2 Location | E62G |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was 22 times better recognized than the variant, making the variant a partial escape. |
| Variant ID. | 982 |
|---|---|
| Epitope Seq. | YETEVHNVW |
| Variant Seq. | YdTEVHNVW |
| Mutations | E/D |
| Epitope Location | E2D |
| HXB2 Location | E62D |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was 13 times better recognized than the variant, making the variant a partial escape. |
| Variant ID. | 983 |
|---|---|
| Epitope Seq. | YETEVHNVW |
| Variant Seq. | YETEaHNVW |
| Mutations | V/A |
| Epitope Location | V5A |
| HXB2 Location | V65A |
| Mutation Type | SF: susceptible form |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Positions 2 and 5 in the epitope had potentially experienced positive selection. The variant was recognized by CTLs to a similar extent as the wt form of the epitope. |
| Variant ID. | 984 |
|---|---|
| Epitope Seq. | YETEVHNVW |
| Variant Seq. | YdTEaHNVW |
| Mutations | E/D V/A |
| Epitope Location | E2D V5A |
| HXB2 Location | E62D V65A |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Positions 2 and 5 in the epitope had potentially experienced positive selection. Wt form of the epitope was >83 times better recognized than the variant, making the variant a partial escape. |
Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.