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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 54157

HXB2 Location  Vpu(74-82)   Vpu Epitope Map
View variants at this location
Epitope HAPWDVNDL   Epitope Alignment
Variants
HAPWDVNDm   susceptible form
Epitope Name HL9
Species (MHC/HLA human(C*01:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  975
Epitope Seq.  HAPWDVNDL
Variant Seq.  HAPWDVNDm
Mutations L/M
Epitope Location L9M
HXB2 Location L82M
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Last position (9) in the epitope had potentially experienced positive selection. The variant was recognized by CTLs to at a better extent than the wt form of the epitope.

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


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