HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Pol(283-290) | Pol Epitope Map
View variants at this location |
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| Epitope |
TAFTIPSI
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Epitope Alignment | ||||||||||
| Variants |
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| Epitope Name | TI8 | |||||||||||
| Species (MHC/HLA) | human(B*51:01) | |||||||||||
Showing all: 3 variant(s).
| Variant ID. | 958 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSt |
| Mutations | I/T |
| Epitope Location | I8T |
| HXB2 Location | I290T |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Last position (8) of the epitope had potentially experienced positive selection. Wt form of the epitope was >100 times better recognized than the variant, making the variant a partial escape. |
| Variant ID. | 959 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSr |
| Mutations | I/R |
| Epitope Location | I8R |
| HXB2 Location | I290R |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Last position (8) of the epitope had potentially experienced positive selection. Wt form of the epitope was >100 times better recognized than the variant, making the variant a partial escape. |
| Variant ID. | 960 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSv |
| Mutations | I/V |
| Epitope Location | I8V |
| HXB2 Location | I290V |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Last position (8) of the epitope had potentially experienced positive selection. Wt form of the epitope was >100 times better recognized than the variant, making the variant a partial escape. |
Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.