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Found 1 matching record:

Displaying record number 53925

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KkWIImGLNK   diminished HLA binding or increased off-rate; escape documented in this paper
KqWIImGLNK   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(B27)

Variant Details

Showing all: 2 variant(s).


Variant ID.  57
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding
Note Previously reported escape (R2K) variant, confirmed here by lack of EliSpot response in 4 individuals and 348-fold decrease in binding to HLA B27.


Variant ID.  58
Epitope Seq.  KRWIILGLNK
Variant Seq.  KqWIImGLNK
Mutations R/Q L/M
Epitope Location R2Q L6M
HXB2 Location R264Q L268M
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding
Note Novel escape variant (R2Q), confirmed by lack of EliSpot response in 4 individuals and 30-fold decrease in binding to HLA B27. The escape mutation is R2Q, since HLA binding to KRWIImGLNK is comparable to KRWIILGLNK binding.

References

Ammaranond2005 Palanee Ammaranond, John Zaunders, Claudette Satchell, David van Bockel, David A. Cooper, and Anthony D. Kelleher. A New Variant Cytotoxic T Lymphocyte Escape Mutation in HLA-B27-Positive Individuals Infected with HIV Type 1. AIDS Res. Hum. Retroviruses, 21(5):395-397, May 2005. PubMed ID: 15929701. Show all entries for this paper.


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