HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 53844

HXB2 Location  Gag(11-19)   Gag Epitope Map
View variants at this location
Epitope GELDRWEKI   Epitope Alignment
GELDRWkKI   diminished response; literature escape
Epitope Name GI9
Species (MHC/HLA human(B*40)

Variant Details

Showing all: 1 variant(s).

Variant ID.  1569
Epitope Seq.  GELDRWEKI
Variant Seq.  GELDRWkKI
Mutations E/K
Epitope Location E7K
HXB2 Location E17K
Mutation Type DR: diminished response
LE: literature escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-B40-carrying mother, M-1002, but was never detected in her non-HLA-B40-carrying infant, P-1031. Decreased recognition of the E17K variant relative to the index epitope was seen in the mother.


Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.

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