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Displaying record number 53839

HXB2 Location Gag(20-29) Gag Epitope Map
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RLRPGGKKKY

`RLRPGGKKqY`		diminished response
`RLRPGGKKrY`		diminished response

Epitope Name RY10

Species (MHC/HLA) human(A*30)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`1571`
Epitope Seq.	`RLRPGGKKKY`
Variant Seq.	`RLRPGGKKqY`
Mutations	K/Q
Epitope Location	K9Q
HXB2 Location	K28Q
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A30 allele carrying mother, M-1003, as well as her non-HLA-A30-carrying infant, P-1189. Decreased recognition of the variant was seen relative to index epitope. This variant was still detected at 12 months of age in Infant P-1189.

Variant ID.	`1572`
Epitope Seq.	`RLRPGGKKKY`
Variant Seq.	`RLRPGGKKrY`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K28R
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This variant from the HXB2 sequence was present in the restricting HLA-A30 allele carrying mother, M-1002, as well as her HLA-A30-carrying infant, P-1031. Decreased recognition of the variant was seen relative to index epitope in the mother. The variant was detected at decreasing frequencies by 11 months of age in infant P-1031, but recognition was equivalent to index epitope recognition in the infant.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.