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Found 1 matching record:

Displaying record number 53834

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KqWIIiGLNK   literature escape
KqWvImGLNK   observed variant
Species (MHC/HLA human(B27)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1417
Epitope Seq.  KRWIILGLNK
Variant Seq.  KqWIIiGLNK
Mutations R/Q L/I
Epitope Location R2Q L6I
HXB2 Location R264Q L268I
Mutation Type LE: literature escape
Method Sequence
Note This variant was seen in an HLA-B27 carrying father, and it was passed on to the non-B27-mother.


Variant ID.  1418
Epitope Seq.  KRWIILGLNK
Variant Seq.  KqWvImGLNK
Mutations R/Q I/V L/M
Epitope Location R2Q I4V L6M
HXB2 Location R264Q I266V L268M
Mutation Type OV: observed variant
Method Sequence
Note This variant arose in a non-B27 mother and it was transmitted to the infant who did carry the restricting HLA allele, B27.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


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