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Found 1 matching record:

Displaying record number 53829

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGVRYPL   Epitope Alignment
Variants
TsGPGVRYPL   diminished HLA binding or increased off-rate; escape documented in this paper
TqGPGVRYPL   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(B*4201)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1429
Epitope Seq.  TPGPGVRYPL
Variant Seq.  TsGPGVRYPL
Mutations P/S
Epitope Location P2S
HXB2 Location P129S
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This index epitope from mother, M4 was transmitted to infant, I4 in whom the variant form which had reduced binding to HLA-B*4201 was seen by week 26. The variant was unable to elicit a CTL response.


Variant ID.  1430
Epitope Seq.  TPGPGVRYPL
Variant Seq.  TqGPGVRYPL
Mutations P/Q
Epitope Location P2Q
HXB2 Location P129Q
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This index epitope from mother, M4 was transmitted to infant, I4 in whom the variant form which had reduced binding to HLA-B*4201 was seen by week 26. The variant was unable to elicit a CTL response.

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


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