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Found 1 matching record:

Displaying record number 53823

HXB2 Location  gp160(586-593)   gp160 Epitope Map
View variants at this location
Epitope YLKDQQLL   Epitope Alignment
Variants
YLqDQQLL   diminished HLA binding or increased off-rate; escape documented in this paper
Species (MHC/HLA human(B*0801)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1311
Epitope Seq.  YLKDQQLL
Variant Seq.  YLqDQQLL
Mutations K/Q
Epitope Location K3Q
HXB2 Location K588Q
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This anchor residue variant was seen in Donor2 and Recipient2, both of whom carried the restricting HLA-B*0801 allele. It was not recognized by either subject and binding to HLA was greatly reduced.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


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