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Found 1 matching record:

Displaying record number 53777

HXB2 Location  Pol(743-751)   Pol Epitope Map
View variants at this location
Epitope LPPIVAKEI   Epitope Alignment
Variants
LPPvVAKEI   HLA association; observed variant
Epitope Name LI9
Species (MHC/HLA human(B51)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3073
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPvVAKEI
Mutations I/V
Epitope Location I4V
HXB2 Location I746V
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C
Variant Subtype B, C
Method Sequence
Note Variant LPPvVAKEI (I31V) is found in both clades B and C. For Clade C, the consensus 31I form is present in 68% B*51- subjects, but the variant 31V form is present in all 6/6 B*51+ subjects. The 31V form is stably transmitted from B*51+ donors to B*51- recipients. In B-clade, where HLA-B*51 is not rare (as in C-clade, South Africa), the 31V form has become the consensus.

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


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