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Found 1 matching record:

Displaying record number 53768

HXB2 Location  Nef(86-94)   Nef Epitope Map
View variants at this location
Epitope DLSHFLKEK   Epitope Alignment
Variants
DLSfFLKEK   observed variant
DLSfFLiEK   observed variant
DLSfFLrEK   observed variant
DLSfFLKEq   observed variant
DLSfFLrEq   observed variant
Species (MHC/HLA human(A*03, A*11)

Variant Details

Showing all: 5 variant(s).


Variant ID.  855
Epitope Seq.  DLSHFLKEK
Variant Seq.  DLSfFLKEK
Mutations H/F
Epitope Location H4F
HXB2 Location H89F
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype CRF01_AE
Method Computer prediction
Note This was the most common variant in CRF01 (18/23 patients). It had the same binding score to HLA as the wt epitope.


Variant ID.  856
Epitope Seq.  DLSHFLKEK
Variant Seq.  DLSfFLiEK
Mutations H/F K/I
Epitope Location H4F K7I
HXB2 Location H89F K92I
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype CRF01_AE
Note Variant found in 1/23 patients infected with CRF01_AE.


Variant ID.  857
Epitope Seq.  DLSHFLKEK
Variant Seq.  DLSfFLrEK
Mutations H/F K/R
Epitope Location H4F K7R
HXB2 Location H89F K92R
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype CRF01_AE
Note Variant found in 2/23 patients infected with CRF01_AE.


Variant ID.  858
Epitope Seq.  DLSHFLKEK
Variant Seq.  DLSfFLKEq
Mutations H/F K/Q
Epitope Location H4F K9Q
HXB2 Location H89F K94Q
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype CRF01_AE
Note Variant found in 1/23 patients infected with CRF01_AE.


Variant ID.  859
Epitope Seq.  DLSHFLKEK
Variant Seq.  DLSfFLrEq
Mutations H/F K/R K/Q
Epitope Location H4F K7R K9Q
HXB2 Location H89F K92R K94Q
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype CRF01_AE
Note Variant found in 1/23 patients infected with CRF01_AE.

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.


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