HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(275-282) | Gag Epitope Map
View variants at this location |
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| Epitope |
RMYSPTSI
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Epitope Alignment | ||||||||||||||||
| Variants |
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| Epitope Name | RI8 | |||||||||||||||||
| Species (MHC/HLA) | human(B52) | |||||||||||||||||
Showing all: 5 variant(s).
| Variant ID. | 760 |
|---|---|
| Epitope Seq. | RMYSPTSI |
| Variant Seq. | RMYSPvSI |
| Mutations | T/V |
| Epitope Location | T6V |
| HXB2 Location | T280V |
| Mutation Type | DR: diminished response |
| Method | CD8 T-cell Elispot - IFNy, Chromium-release assay |
| Note | Variant dominated in the beginning of a 7 year period in a patient and reverted to wt later on. The variant was less well recognized by patient CTLs compared to the wt form. |
| Variant ID. | 761 |
|---|---|
| Epitope Seq. | RMYSPTSI |
| Variant Seq. | RMYSPvgI |
| Mutations | T/V S/G |
| Epitope Location | T6V S7G |
| HXB2 Location | T280V S281G |
| Mutation Type | OV: observed variant |
| Note | Variant was found in 1/8 clones at the beginning of a 7 year period in a patient. |
| Variant ID. | 762 |
|---|---|
| Epitope Seq. | RMYSPTSI |
| Variant Seq. | RMYSPvSt |
| Mutations | T/V I/T |
| Epitope Location | T6V I8T |
| HXB2 Location | T280V I282T |
| Mutation Type | OV: observed variant |
| Note | Variant was found in 1/15 clones at the middle of a 7 year period in a patient. |
| Variant ID. | 763 |
|---|---|
| Epitope Seq. | RMYSPTSI |
| Variant Seq. | RMYSPsSI |
| Mutations | T/S |
| Epitope Location | T6S |
| HXB2 Location | T280S |
| Mutation Type | OV: observed variant |
| Note | Variant was found in 3/15 clones at the middle of a 7 year period in a patient. |
| Variant ID. | 764 |
|---|---|
| Epitope Seq. | RMYSPTSI |
| Variant Seq. | RvYSPTSI |
| Mutations | M/V |
| Epitope Location | M2V |
| HXB2 Location | M276V |
| Mutation Type | OV: observed variant |
| Note | Variant was found in 1/13 clones at the middle of a 7 year period in a patient. |
Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.