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Found 1 matching record:

Displaying record number 53758

HXB2 Location  Gag(275-282)   Gag Epitope Map
View variants at this location
Epitope RMYSPTSI   Epitope Alignment
Variants
RMYSPvSI   diminished response
RMYSPvgI   observed variant
RMYSPvSt   observed variant
RMYSPsSI   observed variant
RvYSPTSI   observed variant
Epitope Name RI8
Species (MHC/HLA human(B52)

Variant Details

Showing all: 5 variant(s).


Variant ID.  760
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPvSI
Mutations T/V
Epitope Location T6V
HXB2 Location T280V
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant dominated in the beginning of a 7 year period in a patient and reverted to wt later on. The variant was less well recognized by patient CTLs compared to the wt form.


Variant ID.  761
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPvgI
Mutations T/V S/G
Epitope Location T6V S7G
HXB2 Location T280V S281G
Mutation Type OV: observed variant
Note Variant was found in 1/8 clones at the beginning of a 7 year period in a patient.


Variant ID.  762
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPvSt
Mutations T/V I/T
Epitope Location T6V I8T
HXB2 Location T280V I282T
Mutation Type OV: observed variant
Note Variant was found in 1/15 clones at the middle of a 7 year period in a patient.


Variant ID.  763
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPsSI
Mutations T/S
Epitope Location T6S
HXB2 Location T280S
Mutation Type OV: observed variant
Note Variant was found in 3/15 clones at the middle of a 7 year period in a patient.


Variant ID.  764
Epitope Seq.  RMYSPTSI
Variant Seq.  RvYSPTSI
Mutations M/V
Epitope Location M2V
HXB2 Location M276V
Mutation Type OV: observed variant
Note Variant was found in 1/13 clones at the middle of a 7 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


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