HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Nef(106-114) | Nef Epitope Map
View variants at this location |
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| Epitope |
RQDILDLWI
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Epitope Alignment | |||||||||||||||||||
| Variants |
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| Epitope Name | RI9 | ||||||||||||||||||||
| Species (MHC/HLA) | human(B13) | ||||||||||||||||||||
Showing all: 6 variant(s).
| Variant ID. | 415 |
|---|---|
| Epitope Seq. | RQDILDLWI |
| Variant Seq. | RQDILDLWv |
| Mutations | I/V |
| Epitope Location | I9V |
| HXB2 Location | I114V |
| Mutation Type | SF: susceptible form |
| Note | Equally well recognized as the wt epitope. |
| Variant ID. | 416 |
|---|---|
| Epitope Seq. | RQDILDLWI |
| Variant Seq. | RkDILDLWI |
| Mutations | Q/K |
| Epitope Location | Q2K |
| HXB2 Location | Q107K |
| Mutation Type | DR: diminished response |
| Note | Variant less well recognized by the CTLs. |
| Variant ID. | 417 |
|---|---|
| Epitope Seq. | RQDILDLWI |
| Variant Seq. | RQeILDLWI |
| Mutations | D/E |
| Epitope Location | D3E |
| HXB2 Location | D108E |
| Mutation Type | DR: diminished response |
| Note | Variant less well recognized by the CTLs. |
| Variant ID. | 418 |
|---|---|
| Epitope Seq. | RQDILDLWI |
| Variant Seq. | aQDILDLWI |
| Mutations | R/A |
| Epitope Location | R1A |
| HXB2 Location | R106A |
| Mutation Type | DR: diminished response |
| Note | The artificial substitution resulted in dramatic decrease, but not total loss of recognition by the CTLs. |
| Variant ID. | 419 |
|---|---|
| Epitope Seq. | RQDILDLWI |
| Variant Seq. | RQaILDLWI |
| Mutations | D/A |
| Epitope Location | D3A |
| HXB2 Location | D108A |
| Mutation Type | DR: diminished response |
| Note | Variant less well recognized by the CTLs. |
| Variant ID. | 420 |
|---|---|
| Epitope Seq. | RQDILDLWI |
| Variant Seq. | RrDILDLWv |
| Mutations | Q/R I/V |
| Epitope Location | Q2R I9V |
| HXB2 Location | Q107R I114V |
| Mutation Type | DR: diminished response |
| Note | Variant less well recognized by the CTLs. |
Harrer2005b Ellen G. Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M. Müller, Bernd M. Spriewald, and Thomas Harrer. A Conserved HLA B13-Restricted Cytotoxic T Lymphocyte Epitope in Nef is a Dominant Epitope in HLA B13-Positive HIV-1-Infected Patients. AIDS, 19(7):734-735, 29 Apr 2005. PubMed ID: 15821402. Show all entries for this paper.