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Displaying record number 53706

HXB2 Location  Nef(106-114)   Nef Epitope Map
View variants at this location
Epitope RQDILDLWI   Epitope Alignment
Variants
RQDILDLWv   susceptible form
RkDILDLWI   diminished response
RQeILDLWI   diminished response
aQDILDLWI   diminished response
RQaILDLWI   diminished response
RrDILDLWv   diminished response
Epitope Name RI9
Species (MHC/HLA human(B13)

Variant Details

Showing all: 6 variant(s).


Variant ID.  415
Epitope Seq.  RQDILDLWI
Variant Seq.  RQDILDLWv
Mutations I/V
Epitope Location I9V
HXB2 Location I114V
Mutation Type SF: susceptible form
Note Equally well recognized as the wt epitope.


Variant ID.  416
Epitope Seq.  RQDILDLWI
Variant Seq.  RkDILDLWI
Mutations Q/K
Epitope Location Q2K
HXB2 Location Q107K
Mutation Type DR: diminished response
Note Variant less well recognized by the CTLs.


Variant ID.  417
Epitope Seq.  RQDILDLWI
Variant Seq.  RQeILDLWI
Mutations D/E
Epitope Location D3E
HXB2 Location D108E
Mutation Type DR: diminished response
Note Variant less well recognized by the CTLs.


Variant ID.  418
Epitope Seq.  RQDILDLWI
Variant Seq.  aQDILDLWI
Mutations R/A
Epitope Location R1A
HXB2 Location R106A
Mutation Type DR: diminished response
Note The artificial substitution resulted in dramatic decrease, but not total loss of recognition by the CTLs.


Variant ID.  419
Epitope Seq.  RQDILDLWI
Variant Seq.  RQaILDLWI
Mutations D/A
Epitope Location D3A
HXB2 Location D108A
Mutation Type DR: diminished response
Note Variant less well recognized by the CTLs.


Variant ID.  420
Epitope Seq.  RQDILDLWI
Variant Seq.  RrDILDLWv
Mutations Q/R I/V
Epitope Location Q2R I9V
HXB2 Location Q107R I114V
Mutation Type DR: diminished response
Note Variant less well recognized by the CTLs.

References

Harrer2005b Ellen G. Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M. Müller, Bernd M. Spriewald, and Thomas Harrer. A Conserved HLA B13-Restricted Cytotoxic T Lymphocyte Epitope in Nef is a Dominant Epitope in HLA B13-Positive HIV-1-Infected Patients. AIDS, 19(7):734-735, 29 Apr 2005. PubMed ID: 15821402. Show all entries for this paper.


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