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Found 1 matching record:

Displaying record number 53682

HXB2 Location  Gag(421-432)   Gag Epitope Map
View variants at this location
Epitope HQMKDCNERQAN   Epitope Alignment
Variants
HQMKDCNtR(qg)QAN   observed variant
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2280
Epitope Seq.  HQMKDCNERQAN
Variant Seq.  HQMKDCNtR(qg)QAN
Mutations E/T -/Q -/G
Epitope Location E8T -(9.1)Q -(9.2)G
HXB2 Location E428T -(429.1)Q -(429.2)G
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


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