Found 1 matching record:
HXB2 Location | Gag(147-155) | Gag Epitope Map
View variants at this location |
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Epitope |
ISPRTLNAW
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Epitope Alignment | |||||||
Variants |
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Epitope Name | ISW9 | ||||||||
Species (MHC/HLA) | human(B*58:01, B57) |
Showing all: 2 variant(s).
Variant ID. | 196 |
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Epitope Seq. | ISPRTLNAW |
Variant Seq. | lSPRTLNAW |
Mutations | I/L |
Epitope Location | I1L |
HXB2 Location | I147L |
Mutation Type | IE: inferred escape |
Method | Sequence |
Note | ISPRTLNAW was recognized more often in children than in adults, and was the most frequently recognized B57 epitope in children. Longitudinal sequencing of 2 HLA B57-positive children born to HLA B57-negative mothers and HIV-negative fathers showed variants of this epitope: p|lSPRTLNAW, and lSPRTLNAW. In both cases the mother carried A|ISPRTLNAW, confirming that the mutations arose under selective pressure in the children following vertical transmission. Response to the variants was not studied. |
Variant ID. | 2324 |
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Epitope Seq. | {A}ISPRTLNAW |
Variant Seq. | {p}lSPRTLNAW |
Mutations | A/P I/L |
Epitope Location | A-1P I1L |
HXB2 Location | A146P I147L |
Mutation Type | IE: inferred escape P: processing |
Method | Sequence |
Note | ISPRTLNAW was recognized more often in children than in adults, and was the most frequently recognized B57 epitope in children. Longitudinal sequencing of 2 HLA B57 children born to HLA B57-negative mothers and HIV-negative fathers showed variants of this epitope: {p}lSPRTLNAW, and lSPRTLNAW. In both cases the mother carried {A}ISPRTLNAW, confirming that the mutations arose under selection pressure in the children following vertical transmission. Response to the variants was not studied, but a processing escape was assumed. |
Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.
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