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Found 1 matching record:

Displaying record number 53619

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KgWIILGLNK   escape documented in this paper
Epitope Name KK10
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 1 variant(s).


Variant ID.  75
Epitope Seq.  KRWIILGLNK
Variant Seq.  KgWIILGLNK
Mutations R/G
Epitope Location R2G
HXB2 Location R264G
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note The infecting virus escaped the vaccine-induced T-cell response with an R264G substitution, KgWIILGLNK, which diminishes binding to B27, between the second and third year of infection.

References

Betts2005 Michael R. Betts, Barbara Exley, David A. Price, Anju Bansal, Zenaido Tres Camacho, Vanessa Teaberry, Sadie M. West, David R. Ambrozak, Georgia Tomaras, Mario Roederer, J. Michael Kilby, Jim Tartaglia, Robert Belshe, Feng Gao, Daniel C. Douek, Kent J. Weinhold, Richard A. Koup, Paul Goepfert, and Guido Ferrari. Characterization of Functional and Phenotypic Changes in Anti-Gag Vaccine-Induced T Cell Responses and Their Role in Protection after HIV-1 Infection. Proc. Natl. Acad. Sci. U.S.A., 102(12):4512-4517, 22 Mar 2005. PubMed ID: 15753288. Show all entries for this paper.


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