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Displaying record number 53619

HXB2 Location Gag(263-272) Gag Epitope Map
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Epitope

KRWIILGLNK

Epitope Alignment

Variants

KgWIILGLNK escape documented in this paper

Epitope Name KK10

Species (MHC/HLA) human(B*27:05)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`75`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KgWIILGLNK`
Mutations	R/G
Epitope Location	R2G
HXB2 Location	R264G
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	The infecting virus escaped the vaccine-induced T-cell response with an R264G substitution, KgWIILGLNK, which diminishes binding to B27, between the second and third year of infection.

References

Betts2005 Michael R. Betts, Barbara Exley, David A. Price, Anju Bansal, Zenaido Tres Camacho, Vanessa Teaberry, Sadie M. West, David R. Ambrozak, Georgia Tomaras, Mario Roederer, J. Michael Kilby, Jim Tartaglia, Robert Belshe, Feng Gao, Daniel C. Douek, Kent J. Weinhold, Richard A. Koup, Paul Goepfert, and Guido Ferrari. Characterization of Functional and Phenotypic Changes in Anti-Gag Vaccine-Induced T Cell Responses and Their Role in Protection after HIV-1 Infection. Proc. Natl. Acad. Sci. U.S.A., 102(12):4512-4517, 22 Mar 2005. PubMed ID: 15753288. Show all entries for this paper.