HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Vpr(59-67)|| Vpr Epitope Map
View variants at this location
Showing all: 1 variant(s).
|Mutation Type||DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
|Method||CD8 T-cell Elispot - IFNy, Chromium-release assay, HLA binding|
|Note||ALIRILQQL bound substantially better to HLA-A2 superfamily than variant AIIRILQQL. Either the virus in all of the individuals mounting a Vpr59-67-specific CD8+ T-cell response exhibited very early escape from the I60 to the I60L prior to first sequencing or only individuals infected with the I60L variant were able to develop epitope-specific CD8+ T-cell responses during primary infection.|
Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.