HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 53534

HXB2 Location  Vif(127-135)   Vif Epitope Map
View variants at this location
Epitope HIVSPRCEY   Epitope Alignment
HIgSPRCEY   susceptible form
Epitope Name HY9
Species (MHC/HLA human(A29)

Variant Details

Showing all: 1 variant(s).

Variant ID.  38
Epitope Seq.  HIVSPRCEY
Variant Seq.  HIgSPRCEY
Mutations V/G
Epitope Location V3G
HXB2 Location V129G
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Longitudinal study of four clade B-infected patients studied for up to 5 years after acute infection. This mutation was observed in a CD8 targeted epitope in subject AC-16 who caries HLA-A29. Response could only be detected with autologous peptide.


Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.

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