HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 53519

HXB2 Location  Vpr(19-28)   Vpr Epitope Map
View variants at this location
Epitope TLEILEELKN   Epitope Alignment
aLEILEELKN   susceptible form
Epitope Name TN10
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).

Variant ID.  39
Epitope Seq.  TLEILEELKN
Variant Seq.  aLEILEELKN
Mutations T/A
Epitope Location T1A
HXB2 Location T19A
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Longitudinal study of four clade B-infected patients studied for up to 5 years after acute infection. This mutation was observed in a CD8 targeted partially mapped novel epitope in subject AC-38 who caries HLA-A3. Responses could only be detected with autologous peptide.


Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.

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