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Found 1 matching record:

Displaying record number 53477

HXB2 Location  Rev(67-75)   Rev Epitope Map
View variants at this location
Epitope SAEPVPLQL   Epitope Alignment
Variants
SAEPgPLQL   escape documented in this paper
Epitope Name SL9
Species (MHC/HLA human(Cw5)

Variant Details

Showing all: 1 variant(s).


Variant ID.  37
Epitope Seq.  SAEPVPLQL
Variant Seq.  SAEPgPLQL
Mutations V/G
Epitope Location V5G
HXB2 Location V71G
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note Variant resulted in dramatic loss of the original CD8 response.

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


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