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Found 1 matching record:

Displaying record number 53476

HXB2 Location  Tat(30-37)   Tat Epitope Map
View variants at this location
Epitope CCFHCQVC   Epitope Alignment
Variants
CCmHCQVC   susceptible form
Epitope Name CC8
Species (MHC/HLA human(C*12)

Variant Details

Showing all: 1 variant(s).


Variant ID.  36
Epitope Seq.  CCFHCQVC
Variant Seq.  CCmHCQVC
Mutations F/M
Epitope Location F3M
HXB2 Location F32M
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note Significant cross-recognition was observed between the escape variant and the wildtype epitope.

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


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