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Found 1 matching record:

Displaying record number 53421

HXB2 Location  Gag(210-218)   Gag Epitope Map
View variants at this location
Epitope AEWDRLHPV   Epitope Alignment
Variants
AEWgRLHPV   observed variant
AdWDRvHPV   observed variant
AE*DRLHPV   observed variant
Epitope Name AEW
Species (MHC/HLA human(A2)

Variant Details

Showing all: 3 variant(s).


Variant ID.  1351
Epitope Seq.  AEWDRLHPV
Variant Seq.  AEWgRLHPV
Mutations D/G
Epitope Location D4G
HXB2 Location D213G
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.


Variant ID.  1352
Epitope Seq.  AEWDRLHPV
Variant Seq.  AdWDRvHPV
Mutations E/D L/V
Epitope Location E2D L6V
HXB2 Location E211D L215V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/18 viral clones contained this variant sequence at the first time point tested after infection.


Variant ID.  2302
Epitope Seq.  AEWDRLHPV
Variant Seq.  AE*DRLHPV
Mutations W/*
Epitope Location W3*
HXB2 Location W212*
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This index epitope sequence had variants at position 3 that were not specified in the paper. Only 2/18 viral clones contained variant sequences at the first time-point tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


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