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Found 1 matching record:

Displaying record number 53418

HXB2 Location  Tat(39-49)   Tat Epitope Map
View variants at this location
Epitope ITKGLGISYGR   Epitope Alignment
Variants
tTKGLGISYGR   observed variant
ITKGsGISYGR   observed variant
Epitope Name ITK
Species (MHC/HLA human(A*6801)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1368
Epitope Seq.  ITKGLGISYGR
Variant Seq.  tTKGLGISYGR
Mutations I/T
Epitope Location I1T
HXB2 Location I39T
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note 4/13 viral clones contained this variant sequence at the first time point (Day 60) tested after infection. While no variant sequence was detected at the second sampling, 2/13 clones contained it at the third time point (Day 369) and the sequence was lost thereafter.


Variant ID.  1369
Epitope Seq.  ITKGLGISYGR
Variant Seq.  ITKGsGISYGR
Mutations L/S
Epitope Location L5S
HXB2 Location L43S
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Only 1/17 viral clones contained this variant sequence at the last time point (Day 635) tested after infection.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


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