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Found 1 matching record:

Displaying record number 53412

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTYKGAL   Epitope Alignment
Variants
RPMTYrGAL   observed variant
RPMTYKaAL   observed variant
RPMTYKGAv   observed variant
RPMsYKaAL   observed variant
RPMTfKGAL   observed variant
Epitope Name RPM
Species (MHC/HLA human(B7)

Variant Details

Showing all: 5 variant(s).


Variant ID.  1394
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYrGAL
Mutations K/R
Epitope Location K6R
HXB2 Location K82R
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This variant was seen earlier and was proposed to be an escape.


Variant ID.  1395
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKaAL
Mutations G/A
Epitope Location G7A
HXB2 Location G83A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This variant was seen earlier and was proposed to be an escape.


Variant ID.  1396
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKGAv
Mutations L/V
Epitope Location L9V
HXB2 Location L85V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This variant was seen earlier and was proposed to be an escape.


Variant ID.  1397
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMsYKaAL
Mutations T/S G/A
Epitope Location T4S G7A
HXB2 Location T80S G83A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This was one of two most common forms of variants.


Variant ID.  1398
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTfKGAL
Mutations Y/F
Epitope Location Y5F
HXB2 Location Y81F
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note This was one of two most common forms of variants.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


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